help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dvorak, J. C.
Right arrow Articles by Utiger, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dvorak, J. C.
Right arrow Articles by Utiger, R. D.

Journal of Clinical Endocrinology & Metabolism, Vol 44, 582-585, Copyright © 1977 by Endocrine Society

ARTICLES

Immunoreactivity and serum destruction of N3immethyl-trh

JC Dvorak and RD Utiger

Pyroglu-N3immethyl-histidyl-prolineamide (MeTRH) is a more potent stimulator of thyrotropin and prolactin secretion than thyrotropin- releasing hormone (TRH). In this study, the immunoreactivity of MeTRH and its susceptibility to destruction by serum were investigated. When tested in radioimmunoassays employing four different anti-TRH sera. MeTRH had 25 to 60% of the immunoreactivity of TRH. Serum destroyed theimmunoreactivity of MeTRH at one-half of the rate at which TRH was destroyed. Slow degradation alone would not appear to explain the potency of MeTRH.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1977 by The Endocrine Society