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Journal of Clinical Endocrinology & Metabolism, Vol 44, 340-345, Copyright © 1977 by Endocrine Society

ARTICLES

Endocrine and cytogenetic studies in a patient with Turner's phenotype and a ring chromosome

RM Boyar, RH Wu, PY Liao and JW Finkelstein

A 27-year-old woman with secondary amenorrhea and some of the somatic stigmata of Turner's syndrome was found to have a ring chromosome. Laparoscopy and ovarian biopsy showed hypoplastic ovaries and an absence of primordial follicles. Endocrine evaluation showed a normal 24-h mean LH level (12.5 mIU/ml), an elevated FSH level (28 mIU/ml) and a normal plasma estradiol level (64 pg/ml). The augmented FSH and normal LH response to LH-RH is similar to what is found in men with germinal cell aplasia (Sertoli-cell only). The synchronous initiations of normal LH and abnormally augmented FSH secretory episodes in this patient suggests the absence or decrease of some factor normally produced by the ovarian follicle which modulates the release of FSH in response to LH-RH.




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Copyright © 1977 by The Endocrine Society