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LH and FSH Levels in Urine and Serum of Prepubertal and Pubertal Children Receiving a 3 Hour Infusion of LH-RH

Ed Wright Pediatric Endocrinology Research Laboratory, All Children's Hospital St. Petersburg, Florida
The University of South Florida College of Medicine, Department of Pediatrics Tampa, Florida 33612

LH-RH was administered to 17 normal prepubertal and 14 pubertal children as well as to 6 GH deficient prepubertal patients. Urinary immunoreactive LH and FSH were measured in acetone extracts of 3 h collections prior to, during, and immediately after a 3 h infusion of 100 βg LH-RH. Peak LH excretion in response to LH-RH was higher in pubertal than prepubertal children. Girls excreted larger quantities of FSH after LH-RH than did boys. Serum LH and FSH increments evoked by LH-RH correlated significantly (P < 0.01) with peak urinary gonadotropin excretion. These data suggest that measurement of urinary immunoreactive LH and FSH prior to and after LH-RH administration is clinically useful in evaluation of the reproductive endocrine system of young children and of individuals with low basal levels of gonadotropin.

Supported by National Foundation-March of Dimes Grant Nos. 1-323, C-199, and National Foundation-Basil O'Connor Starter Grant No. 5–71.

Received May 17, 1976.

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