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The Effect of Dopamine Infusion on Insulin and Glucagon Secretion in Man¹

Department of Reproductive Medicine, School of Medicine, University of California, San Diego La Jolla, California 92093

Correspondence to S. S. C. Yen.

The effect of dopamine on the release of insulin and glucagon was investigated in eight adult subjects. Dopamine infused iv at a rate of 4 βg/kg/min x 2h, unaccompanied by cardiovascular changes, induced a prompt and significant increase in plasma insulin and glucagon and in plasma glucose levels. These findings suggest that dopamine may stimulate both a and β cells.

¹ Research supported by Rockefeller Foundation Grant RF-75029.

² Former Research Fellow in Reproductive Endocrinology. Present address: Hopital Maisonneuve Lab d/Endocrinologie, 5415 BD L'Assomption, Montreal, Quebec, Canada.

³ Research Fellow in Reproductive Endocrinology, supported by Rockefeller Foundation Grant RF-75029.

⁴ Former Research Fellow in Reproductive Endocrinology. Present address: Harbor General Hospital, Department of Obstetrics and Gynecology, Torrance, California.

Received April 23, 1976.