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Failure of Growth Hormone-Suppressing Agents to Affect TSH-Releasing Hormone- and LH-Releasing Hormone-Induced Growth Hormone Release in Acromegaly^*

Second Department of Medicine, Hokkaido University School of Medicine Sapporo, 060, Japan

In patients with acromegaly whose basal plasma GH levels were suppressed with 9 mg/day of dexamethasone for 2 days, TRH-(6 cases) and LHRH-(1 case) induced GH release were unaffected when the responses were compared to the basal levels. Phentolamine infusion, 70 mg in 150 min, or hyperglycemia induced by iv infusion of 700 ml of 50% glucose solution also did not suppress TRH-induced GH release in 2 acromegalic patients whose basal GH levels were lowered with these agents alone.

These results seem to indicate that dexamethasone does not affect TRH- or LHRH-induced GH release per se, but affects the basal state which determines the absolute level of response. They also support the concept that TRH and LHRH act directly on pituitary tumor cells to release GH in acromegaly.

^* Supported in part by the grants from the Ministry of Health and Welfare and the Ministry of Education of Japan.

Received April 8, 1976.