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Preferential Renal Excretion of Iodide Derived from Thyroxine and Triiodothyronine Deiodination in Man

Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine 880 Mibu-machi, Kitakobayashi, Tochigi, Japan

Tracer doses of ¹³¹I-(Carrier free), ^13II-T₃ and ^13II-T₄ were administered po to 19 healthy male volunteers at intervals 2 to 8 weeks to study whether or not part of the iodide generated in the kidney from T₃ and T₄ deiodination may enter the renal tubular lumen and be excreted in the urine without entering the blood stream. U(urine)/T(thyroid) ratios of the radioactivity from these materials were employed as the index of the comparison. U/T ratios were severalfold higher 24 h after ¹³¹I-T₃ or ¹³¹I-T₄ administration than after ¹³¹I-The data indicate that the ¹³¹I-derived from T₃ and T₄ metabolism is more readily excreted into urine than ^13II-which reaches the kidney as inorganic iodide.

Received September 25, 1974.

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