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Harriet Lane Service, The Johns Hopkins Hospital, Division of Pediatric Endocrinology, Department of Pediatrics, The Johns Hopkins University School of Medicine Baltimore, Maryland 21205
Reprint requests to: James P. Gutai, M.D., Children's Hospital of Pittsburgh, 125 DeSoto Street, Pittsburgh, Pa. 15213.
The 24 h integrated concentrations of progesterone, 17-hydroxyprogesterone (17-OHP) and cortisol were determined in 5 male subjects ranging in age from 25 to 36 years. Using a nonthrombogenic catheter and a constant withdrawal pump, blood was collected for a period of 24 h in 30 min aliquots. All five subjects had similar 24 h integrated concentrations of cortisol (9.2 ± 5.4). One subject had elevated 24 h integrated concentrations of progesterone (55.2 ± 18.7) and 17-OHP (352 ± 122) when compared to the mean integrated concentrations (progesterone: 24.9 ± 4.7; 17-OHP: 109 ± 33) of the 4 other subjects. The 30 min integrated concentrations showed a diurnal variation for both 17-OHP and cortisol but not for progesterone. The best correlation between cortisol and 17-OHP occurred when the concentrations of cortisol were correlated with the concentrations of 17-OHP 90 or 120 min earlier. No significant correlation occurred between cortisol and progesterone.
Supported by U.S. Public Health Services Research Grants HD-6284-04 (AAK), AM-00180-24 (CJM),Traineeship Grant 5-K06-AM-21855-11 (CJM).
The patients were studied on the Clinical ResearchCenter of the Department of Pediatrics, supported by Grant 5-MO-RR-0052 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health.
Received February 17, 1976.
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