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Journal of Clinical Endocrinology & Metabolism, Vol 43, 1418-1421, Copyright © 1976 by Endocrine Society

ARTICLES

Human puberty: 24-hour estradiol in pubertal girls

RM Boyar, RH Wu, H Roffwarg, S Kapen, ED Weitzman, L Hellman and JW Finkelstein

Plasma luteinizing hormone, follicle-stimulating hormone, and estradiol were measured at 20-minute intervals for 24-hours in seven pubertal premenarchal girls whose sleep was monitored polygraphically. A circadian variation in plasma estradiol was demonstrated with the highest values occurring during the day (1400-1600 hours) and lowest values during sleep, a time when gonadotropin secretion was augmented.


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