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Journal of Clinical Endocrinology & Metabolism, Vol 43, 1410-1413, Copyright © 1976 by Endocrine Society

ARTICLES

A low molecular weight substance obtained from serum which has luteinizing hormone like activity ("mini LH")

FA Leidenberger, D Graesslin, HJ Scheel, N Hess, V Lichtenberg and G Bettendorf

A low molecular weight substance of 1000-2000 daltons has been isolated in dialysates of normal human serum which, on testing in a radio- immunoassay, a radioligand receptorassay and an in-vitro bioassay exhibited LH activity comparable to the range of LH activity found in normal serum. The substance was heat labile. Its reactivity in a RIA suggests peptide nature. No "mini LH" activity could be derived from LH- free serum samples of hypophysectomized patients.




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Copyright © 1976 by The Endocrine Society