help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weber, H. P.
Right arrow Articles by Lemann, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weber, H. P.
Right arrow Articles by Lemann, J., Jr

Journal of Clinical Endocrinology & Metabolism, Vol 43, 1047-1055, Copyright © 1976 by Endocrine Society

ARTICLES

The lack of effect of chronic metabolic acidosis on 25-OH-vitamin D metabolism and serum parathyroid hormone in humans

HP Weber, RW Gray, JH Dominguez and J Lemann Jr

We evaluated the turnover of the plasma 25-OH-vitamin D pool, acid, and mineral balances in paired balance studies of 6 normal subjects during normal acid base conditions and during stable chronic metabolic acidosis induced by NH4Cl. Positive acid balances and negative Ca balances due to hypercalciuria were observed as previously reported. Plasma 25-OH-D pool turnover averaged 6.1+/-0.4 nmol/day during control and did not change during acidosis (6.5 +/- 0.5 nmol/day) nor were any significant increments in net intestinal absorption of Ca, PO4, or Mg, the physiological expression of vitamin D action, observed during acidosis. In 3 other subjects, repetitive measurements of serum iPTH during 7 control days and 24 days of stable NH4Cl acidosis showed no changes. We interpret the data to support the hypothesis that neither PTH nor vitamin D and its metabolites mediates the increase in net bone resorption that must accompany chronic metabolic acidosis.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. Charoenphandhu, K. Tudpor, N. Pulsook, and N. Krishnamra
Chronic metabolic acidosis stimulated transcellular and solvent drag-induced calcium transport in the duodenum of female rats
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G446 - G455.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Lemann Jr., D. A. Bushinsky, and L. L. Hamm
Bone buffering of acid and base in humans
Am J Physiol Renal Physiol, November 1, 2003; 285(5): F811 - F832.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. YALCINDAG, J. SILVER, and T. NAVEH-MANY
Mechanism of Increased Parathyroid Hormone mRNA in Experimental Uremia: Roles of Protein RNA Binding and RNA Degradation
J. Am. Soc. Nephrol., December 1, 1999; 10(12): 2562 - 2568.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
N. Ashizawa, R. Fujimura, K. Tokuyama, and M. Suzuki
A bout of resistance exercise increases urinary calcium independently of osteoclastic activation in men
J Appl Physiol, October 1, 1997; 83(4): 1159 - 1163.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1976 by The Endocrine Society