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Journal of Clinical Endocrinology & Metabolism, Vol 43, 944-947, Copyright © 1976 by Endocrine Society

ARTICLES

Study on the relationship between plasma prolactin levels and androgen metabolism in man

B Magrini, JR Ebiner, P Burckhardt and JP Felber

The purpose of the study was to investigate the effect of hyperprolactinemia on the metabolism of androgens in man. A group of 6 normal men was treated for 4 consecutive days, on separate periods, with Sulpiride which is known to raise plasma prolactin (PRL) concentration. The effect of the treatment on plasma steroids was verified in basal conditions and under stimulation by HCG. In the controls, a parallel rise in testosterone (T) and dihydrotestosterone (DHT) was observed in response to HCG stimulation. In experimental hyperprolactinemia, the rise in T in response to HCG, similar to that of the controls, was accompanied by a markedly diminished rise in DHT. Similar results were observed in a patient with hyperprolactinemia following apparent accidental section of the pituitary stalk. These data demonstrate the interference of increased levels of PRL in the metabolism of testosterone into the active DHT form by 5alpha- reductase. They suggest that this mechanism could possibly impair the gonadal function in man.




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Copyright © 1976 by The Endocrine Society