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Gonadotropin Output in Congenital Adrenal Hyperplasia before and after Adrenal Suppression

¹ Pediatric Endocrine Clinic, The Johns Hopkins University School of Medicine Baltimore, Maryland 21205
² Department of Gynecology & Obstetrics, Division of Endocrinology, The Johns Hopkins University School of Medicine Baltimore, Maryland 21205

Basal release of gonadotropin and the response to an infusion of 100 µg of syntheticluteinizing hormone releasing hormone (LRH) were studied in a teenage girl with congenital adrenal hyperplasia (CAH). The initial study was done during a period of poor adrenal suppression, and the second study was done after adequate adrenal suppression was achieved. To assess adrenal function, circulating levels of adrenal steroid hormones were evaluated continuously over a 24 h period. During the period of increased production of adrenal androgens, the pattern of gonadotropin release was that of a prepubertal child. After 3 months of adrenal suppression the pattern of gonadotropin secretion was similar to that of a normal girl in mid-puberty. This demonstrates the rapidchange from prepubertal to pubertal gonadotropin dynamics in a teenage patient following adequate suppression of androgens from the adrenal.

Supported in part by grants: The Stetler Research Fund for Women Physicians (GJK), ResearchGrant AM 00180-25, Research Career Award 5-K06-AM 21855-10 (CJM), and the Hospital for Consumptivesof Maryland (Eudowood), Baltimore, Md., and United States Public Health Service, and Clinical Research Centers Grant 5-M01-RR-0052 of the Division of Research Resources, National Institute of Health.

³ Present Address: Division of Pediatric Endocrinology, DepartmentofPediatrics, University of Texas Medical Branch, Galveston, Texas 77550.

Received December 4, 1975.

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