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Journal of Clinical Endocrinology & Metabolism, Vol 43, 831-835, Copyright © 1976 by Endocrine Society

ARTICLES

Chemical characterization of ectopic ACTH purified from a malignant thymic carcinoid tumor

PJ Lowry, LH Rees, S Tomlin, G Gillies and J Landon

ACTH was purified from thymic tumor associated with ectopic ACTH production by gel filtration and ion exchange chromatography. Amino acid composition and C- and N-terminal analyses indicated that this tumor ACTH was comprised of the 2-38 sequence of authentic pituitary ACTH. The observations suggest that the mode of cleavage of this tumor ACTH from its precursor is different from that of pituitary ACTH.


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C. DeBold, M. Schworer, T. Connor, R. Bird, and D. Orth
Ectopic pro-opiolipomelanocortin: sequence of cDNA coding for beta-melanocyte-stimulating hormone and beta-endorphin
Science, May 13, 1983; 220(4598): 721 - 723.
[Abstract] [PDF]


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