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Journal of Clinical Endocrinology & Metabolism, Vol 43, 462-465, Copyright © 1976 by Endocrine Society

ARTICLES

Circadian rhythm of insulin-induced hypoglycemia in man

S Sensi and F Capani

Four healthy men were given an insulin tolerance test (0.1 IU/kg BW) six times in different days at the following clock hours: 0400 h, 0800h, 1200 h, 1600 h, 2000 h, and 2400 h, in random order. Four days separated two consecutive tests. The glucose disappearance rate (K value) was calculated for each test between 5 min and 25 min after iv injection of insulin. The statistical evaluation by Cosinor test showed a statistically significant circadian rhythm for the hypoglycemic action of exogenous insulin with a peak at 1030 h (95% condifence limits: 0830 to 1430 h).


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E. Van Cauter, K. S. Polonsky, and A. J. Scheen
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Endocr. Rev., October 1, 1997; 18(5): 716 - 738.
[Abstract] [Full Text]


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