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Journal of Clinical Endocrinology & Metabolism, Vol 43, 453-456, Copyright © 1976 by Endocrine Society

ARTICLES

Suppression by thyrotropin-releasing hormone (TRH) of growth hormone release induced by arginine and insulin-induced hypoglycemia in man

K Maeda, Y Kato, K Chihara, S Ohgo and Y Iwasaki

Plasma growth hormone (GH) levels were significantly increased following L-arginine (30 g) infusion or insulin (0.1 U/kg body wt)- induced hypoglycemia in normal men. When synthetic thyrotropin- releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively. These results suggest a possible inhibitory effect of TRH on GH secretion in man.


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A. Giustina and J. D. Veldhuis
Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human
Endocr. Rev., December 1, 1998; 19(6): 717 - 797.
[Abstract] [Full Text]


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