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Journal of Clinical Endocrinology & Metabolism, Vol 43, 412-418, Copyright © 1976 by Endocrine Society

ARTICLES

Unconjugated cortisol in human amniotic fluid: relationship to lecithin/sphingomyelin ratio

SY Tan, IH Gewolb and JC Hobbins

A specific and thoroughly validated competitive protein binding radioassay has been developed for the measurement of unconjugated cortisol in human amniotic fluid. Cortisol levels rose throughout normal gestation from 8.6 +/- 0.8 ng/ml at less than 20 weeks to 19.8 +/- 1.5 ng/ml at 30-40 weeks. Levels were significantly higher in amniotic fluid samples having mature lecithin/sphingomyelin (L/S) ratios (greater than 2), and good correlation with individual cortisol values was obtained (r = 0.79; P less than 0.001). These results support the hypothesis that cortisol plays a role in fetal lung maturation.




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Copyright © 1976 by The Endocrine Society