help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vaughn, C. B.
Right arrow Articles by Brooks, S. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vaughn, C. B.
Right arrow Articles by Brooks, S. C.

Journal of Clinical Endocrinology & Metabolism, Vol 43, 387-393, Copyright © 1976 by Endocrine Society

ARTICLES

The fate of 17 beta-estradiol in the plasma of premenopausal and postmenopausal patients with cancer

CB Vaughn, D Kolakowski, U Zylka and SC Brooks

The patterns of radioactive estrogen metabolities in the plasma of patients with a variety of malignancies were determined after the injection of physiological amounts of 17 beta-estradiol-6,7-3H or of estrone-6,7-3H. The metabolites were separated and isolated from the plasma by the following procedures: a) alumina chromatography, b) modified Brown procedure, and c) gas liquid chromatography. This study showed that the conjugated state of the estrogens varied with the subjects's age. There was a dramatic decrease in the relative quantity of the plasma free estrogens which are converted to sulfates as the age of the patient increased. This change was noted just prior to menopause, suggesting that there are alterations in the conjugation of plasma estrogens which are detectable before clinical menopause.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1976 by The Endocrine Society