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Thyrotoxicosis Secondary to Involvement of the Thyroid with Malignant Lymphoma

The Division of Medicine, Roswell Park Memorial Institute, New York State Department of Health Buffalo, New York the Department of Medicine, University of California, U.C.L.A. Center for the Health Sciences Los Angeles, California

Reprint requests to: Katsutaro Shimaoka, M.D., Department of Medicine B, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York 14263.

A patient with malignant lymphoma devel oped goiter and thy rotoxicosis during the course of her disease. A thyroid biopsy revealed involvement of the thyroid gland with a malignant lymphoma. This was associated with the high levels of circulating thyroglobulin and thyroid hormones. The patient was treated with propylthiouracil, local radiotherapy, and nitrogen mustard and prednisone. The patient became euthyroid with the disappearance of goiter. Circulating levels of thyroglobulin and thyroid hormones returned to the normal range.

Received May 14, 1975.

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