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ACTIONS OF GROWTH HORMONE-RELEASE INHIBITING HORMONE (SOMATOSTATIN) ON THE RENIN ALDOSTERONE SYSTEM

Endocrine and Renal Units, Department of Medicine University of Newcastle upon Tyne, England Department of Endocrinology, St. Bartholomew's Hospital London, England Veterans Administration Hospital and Department of Medicine Tulane University School of Medicine, New Orleans, Louisiana, U.S.A

Administration of growth hormone-release inhibiting hormone (GH-RIH, somatostatin), as a 90 minute infusion (10 ug/min), to 3 healthy young men under conditions of active renin secretion achieved by pretreatment with furosemide (80 mg daily for 5 days), caused a mean 30% fall in plasma renin activity, which returned to basal levels immediately after stopping the GH-RIH infusion. Plasma aldosterone levels were not affected during the course of this experiment.