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Plasma Gonadotropin and Gonadotropin-Releasing Hormone Levels After Intranasal Administration of Gonadotropin Releasing Hormone

Departments of Obstetrics and Gynaecology University of Cape Town, Cape Town, South Africa

Reprint requests to: Dr. M. Katz, Department of Obstetrics and Gynaecology, Medical School, Observatory 7900, Cape Province, South Africa.

Intranasal administration of gonadotropin-releasing hormone (GnRH) in doses ranging from 2–4 nig produced a consistently prolonged LH response in patients with secondary amenorrhea. In 4 cases, a delayed secondary rise occurred. A similarly prolonged FSH response was observed in the majority of patients. Six hours after intranasal GnRH, FSH and LH values were well above basal levels and were higher than those observed at a similar interval after intravenous GnRH. Plasma GnRH levels after intranasal administration failed to achieve the high peaks found after the intravenous route but maintained elevated levels for at least an hour and often longer. Despite the much lower plasma GnRH levels, intranasal GnRH produced a sustained effect on LH and FSH secretion, greater than GnRH given by the intravenous route.

Received August 25, 1975.