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Journal of Clinical Endocrinology & Metabolism, Vol 43, 205-207, Copyright © 1976 by Endocrine Society

ARTICLES

Somatostatin does not suppress plasma parathyroid hormone

LJ Deftos, M Lorenzi, N Bohanon, E Tsalakian, V Schneider and JE Gerich

The effect of somatostatin on plasma parathyroid hormone (PTH) was studied in 6 subjects with normal parathyroid function and one patient with a parathyroid adenoma. In 5 subjects, including the one with the parathyroid adenoma, plasma PTH was measured by radioimmunoassay during a 4-hour infusion of somatostatin (500 mug/h). In 2 subjects, PTH responses to EDTA were compared with those observed during a simultaneous infusion of somatostatin and EDTA. In no instance was ther a discernible effect of the somatostatin infusion on plasma PTH. These results demonstrate that somatostatin does not suppress plasma PTH.




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Copyright © 1976 by The Endocrine Society