This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by DEFTOS, L. J. Articles by GERICH, J. E. Search for Related Content PubMed PubMed Citation Articles by DEFTOS, L. J. Articles by GERICH, J. E.

Somatostatin Does Not Suppress Plasma Parathyroid Hormone

LEONARD J. DEFTOS^*, MARA LORENZI, NANCY BOHANON, EVA TSALAKIAN, VICTOR SCHNEIDER and JOHN E. GERICH

^* The Departments of Medicine (Endocrinology), University of California at San Diego San Franciscot The Veterans Administration Hospital La Jolla, California
The Metabolic Research Unit San Franciscot
University of California San Francisco

Reprint requests to Dr. Deftos.

The effect of somatostatin on plasma parathyroid hormone (PTH) was studied in 6 subjects with normal parathyroid function and one patient with a parathyroid adenoma. In 5 subjects, including the one with the parathyroid adenoma, plasma PTH was measured by radioimmunoassay during a 4-hour infusion of somatostatin (500 µg/h). In 2 subjects, PTH responses to EDTA were compared with those observed during a simultaneous infusion of somatostatin and EDTA. In no instance was there a discernible effect of the somatostatin infusion on plasma PTH. These results demonstrate that somatostatin does not suppress plasma PTH.

Supported by Grants from the National Institutes of Health (AM 15888, AM07048, AM 12763, and HD08340), the American Cancer Society (PDT-25A), and the Veterans Administration.

Dr. Deftos is a Clinical Investigator of the Veterans Administration.

Received January 2, 1976.