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The Role of 19-Hydroxy-⁴-androstene-3,17-dione in the Conversion of Circulating ⁴-Androstene-3,17-dione to Estrone

Departments of Obstetrics and Gynecology and Biochemistry University of Minnesota School of Medicine, Minneapolis, Minn. 55455 Departments of Obstetrics and Gynecology and Pharmacology, College of Physicians and Surgeons Columbia University, New York, N.Y Obstetrics and Gynecology Service St. Luke's Hospital Center, New York, N.Y.

A mixture of 4-¹⁴C-⁴-androstene-3,17-dione and 6,7-³H-19-hydroxy-⁴-androstene-3,17-dione was intravenously injected into three women, and the ³H/14C ratios in urinary 19-hydroxyandrostenedione and urinary estrogens were determined. The ratios of ³H/¹⁴C in the estrogens were similar to those of the dose, while the ratios in urinary 19-hydroxyandrostenedione were much higher than those of the dose. The fractional conversions of androstenedione to estrone and of 19-hydroxyandrostenedione to estrone are therefore similar. However, little, if any, 19-hydroxyandrostenedione produced during aromatization enters the circulation and mixes with injected 19-hydroxyandrostenedione.

^* Present address: Department of Obstetrics and Gynecology, Maricopa County General Hospital, Phoenix, Arizona 85008.

Received October 7, 1975.