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Integrated Concentrations of Luteinizing Hormone and Puberty

Department of Pediatrics The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Correspondence: Peter A. Lee, M.D., 3-110 Children's Medical Center, The Johns Hopkins Hospital, Baltimore, Maryland 21205.

Integrated serum concentrations of luteinizing hormone have been compared among 30-minute collections from 10 boys (6–18 years old) and 5 girls (5–11 years old). This study suggests that prepubertal as well as pubertal boys have greater mean integrated concentrations of LH during sleep than during waking. One of two pubertal girls had greater concentrations of LH during sleep, while three prepubertal girls did not.

Supported by Research Grants HD-01852, HD-06284-02, and AM-00180-22 and by Traineeship Grant Ti-AM-5219-13 of the National Institutes of Health, United States Public Health Service.

Patients were studied on the Pediatric Clinical Research Unit of the Johns Hopkins Hospital, supported by Grant 5-M01-RR-0052 from the General Research Centers Program of the Division of Research Resources, National Institutes of Health.

Received April 14, 1975.

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