help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parker, K. M.
Right arrow Articles by Eddy, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parker, K. M.
Right arrow Articles by Eddy, R. L.

Journal of Clinical Endocrinology & Metabolism, Vol 42, 1188-1191, Copyright © 1976 by Endocrine Society

ARTICLES

Growth hormone refractory interval to levodopa stimulation

KM Parker and RL Eddy

The GH response to repeat l-dopa stimulation was studied in three phases. In phase I and phase II, 16 normal adults divided into four groups were restimulated at 3, 4, 5, and 6 hours with 500 mg l-dopa and 1000 mg l-dopa, respectively. No response could be elicited at 3 hours and only at 6 hours (500 mg l-dopa) and 5 hours (1000 mg l-dopa) did the repeat responses return in magnitude to that of the initial. The period of decreased responsiveness to GH was terned the "refractory interval". In phase III, addition of an inhibitor of peripheral L- aromatic amino acid decarboxylase (50 mg MK-486) to the restimulation dose shortened but did not eliminate the refractoriness. Our results suggest that the refractory interval is not due to a peripherally located mechanism.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1976 by The Endocrine Society