help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Larsen, P. R.
Right arrow Articles by Parlow, A. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Larsen, P. R.
Right arrow Articles by Parlow, A. F.

Journal of Clinical Endocrinology & Metabolism, Vol 42, 987-990, Copyright © 1976 by Endocrine Society

ARTICLES

Immunoassay of human TSH using dried blood samples

PR Larsen, A Merker and AF Parlow

A sensitive, semi-quantitative radioimmunoassay method to screen for elevations of TSH concentration in blood is described. The method requires two 0.32 cm dots of dried blood-impregnated filter paper (equivalent to 3 mul plasma) and a 3-day incubation. Separation of bound and free is obtained using polyethylene glycol. The method can recognize TSH concentrations as low as 22 muU/ml using a highly sensitive antiserum developed by one of us (AFP). TSH in dried cord and newborn blood from 4 infants with congenital hypothyroidism was clearly higher than in normal infants. The method is suitable for use in a newborn screening program to confirm the suspicion of primary hypothyroidism in specimens with low T4 concentrations.


This article has been cited by other articles:


Home page
 EndocrinologyHome page
C. Boltze, G. Brabant, H. Dralle, R. Gerlach, A. Roessner, and C. Hoang-Vu
Radiation-Induced Thyroid Carcinogenesis as a Function of Time and Dietary Iodine Supply: An in Vivo Model of Tumorigenesis in the Rat
Endocrinology, July 1, 2002; 143(7): 2584 - 2592.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. H. Oppenheimer and H. L. Schwartz
Molecular Basis of Thyroid Hormone-Dependent Brain Development
Endocr. Rev., August 1, 1997; 18(4): 462 - 475.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1976 by The Endocrine Society