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AMNIOTIC FLUID REACTIVITY DETECTED BY SOMATOMEDIN C RADIORECEPTOR ASSAY: CORRELATION WITH GROWTH HORMONE, PROLACTIN AND FETAL RENAL MATURATION

Department of Medicine, Metabolism Division, Perinatal Unit, Department of Obstetrics and Gynecology, Washington University School of Medicine St. Louis, Missouri 63110
Department of Pediatrics, University of North Carolina Chapel Hill, North Carolina 27514

Amniotic fluid was assayed by a radioreceptor assay utilizing ¹²⁵I-somatomedin C and placental membranes. Growth hormone and prolactin levels were measured by radioimmunoassay at different gestational ages (8-41 weeks). Somatomedin receptor activity, growth hormone, and prolactin reached high levels during early gestation (8-26 weeks) displaying different patterns of appearance which reflect fetal serum levels of these hormones. After 26 weeks gestation all these hormones decreased in concentration. This decrease showed a strong correlation with fetal renal maturation as measured by amniotic fluid creatinine levels.

Received February 2, 1976.

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