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Journal of Clinical Endocrinology & Metabolism, Vol 42, 983-986, Copyright © 1976 by Endocrine Society

ARTICLES

Amniotic fluid reactivity detected by somatomedin C radioreceptor assay: correlation with growth hormone, prolactin and fetal renal maturation

RH Chochinov, A Ketupanya, IK Mariz, LE Underwood and WH Daughaday

Amniotic fluid was assayed by a radioreceptor assay utilizing 125I- somatomedin C and placental membranes. Growth hormone and prolactin levels were measured by radioimmunoassay at different gestational ages (8-41 weeks). Somatomedin receptor activity, growth hormone, and prolactin reached high levels during early gestation (8-26 weeks) displaying different patterns of appearance which reflect fetal serum levels of these hormones. After 26 weeks gestation all these hormones decreased in concentration. This decrease showed a strong correlation with fetal renal maturation as measured by amniotic fluid creatinine levels.


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M. A. Underwood and M. P. Sherman
Nutritional Characteristics of Amniotic Fluid
NeoReviews, June 1, 2006; 7(6): e310 - e316.
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