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Journal of Clinical Endocrinology & Metabolism, Vol 42, 970-972, Copyright © 1976 by Endocrine Society

ARTICLES

Lack of release of human chorionic gonadotropin by thyrotropin- releasing hormone

JM Hershman and GN Burrow

To assess the effect of TRH on the secretion of hCG, TRH in doses of 25 to 500 mug was administered to 10 pregnant women of 6 to 12 weeks or 16 to 20 weeks of gestation. There was no significant change in the serum hCG concentration during the ensuing 90 min. In women 6 to 12 weeks pregnant, doses of 25 mug, 100 mug, or 500 mug TRH elicted similar increments to serum TSH. Women 16 to 20 weeks pregnant had a slightly higher baseline TSH and a greater TSH response to TRH than the 6-12 week pregnant group. Although hCG may be an important thyroid stimulator in the first trimester of pregnancy, its secretion is not affected by TRH.




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Copyright © 1976 by The Endocrine Society