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Cortisol-Dihydrotachysterol Antagonism in a Patient with Hypoparathyroidism and Adrenal Insufficiency: Apparent Inhibition of Bone Resorption

Neonatal and Pediatric Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health Bethesda, Md. 20014
Department of Pediatrics, University of Wisconsin Madison, Wisconsin

Reprints: Dr. P. M. Farrell, National Institutes of Health, Bldg. 10, Room 13N226, Bethesda, Maryland 20014.

This report describes a case of chronic mucocutaneous candidiasis with associated hypopara thyroidism and acutely developed adrenocortical insufficiency. The latter was heralded by hypercalcemia. Upon the institution of cortisol therapy, while still under the effects of a vitamin D analog, dihydrotachysterol (DHT), the patient exhibited severe hypocalcemia and tetany. Since calcium intake was minimal during this period of presumed corticosteroid-DHT antagonism, it is suggested that the cortisol disturbed calcium homeostasis by inhibiting bone calcium resorption.

Received March 10, 1975.

This article has been cited by other articles:

				W. F. Streck, C. Waterhouse, and J. G. Haddad Glucocorticoid Effects in Vitamin D Intoxication Arch Intern Med, September 1, 1979; 139(9): 974 - 977. [Abstract] [PDF]