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Journal of Clinical Endocrinology & Metabolism, Vol 42, 926-930, Copyright © 1976 by Endocrine Society

ARTICLES

The acute thyroidal response to iodixed oil in severe endemic goiter

MS Croxson, PD Gluckman and HK Ibbertson

The acute changes in serum thyrotropin (TSH) triiodothyronine (T3) and thyroxine (T4), were measured in 14 subjects, 4 to 10 (mean = 6) days following intramuscular iodized oil injection. In 8 subjects with small or absent goiter there was a significant fall in T3 and a rise in TSH concentrations, suggesting an acute inhibitory effect of the iodine. In 6 subjects with large multinodular goiters there was a marked rise in both T3 and T4, and reduction in the elevated basal TSH. Biochemical hyperthyroidism occurred in 3 of these subjects. The acute thyroid hormone response to iodized oil, whether inhibitory or stimulatory in a particular subject, depends both on goiter size and on the serum concentration of TSH.




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Copyright © 1976 by The Endocrine Society