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The Acute Thyroidal Response to Iodized Oil in Severe Endemic Goiter

The Section of Endocrinology, Department of Medicine, School of Medicine Auckland, New Zealand

Reprints: Dr. H. K. Ibbertson, Section of Endocrinology, Department of Medicine, School of Medicine, Auckland, New Zealand.

The acute changes in serum thyrotropin (TSH) triiodothyronine (T₃) and thyroxine (T₄), were measured in 14 subjects, 4 to 10 (mean = 6) days following intramuscular iodized oil injection. In 8 subjects with small or absent goiter there was a significant fall in T₃ and a rise in TSH concentrations, suggesting an acute inhibitory effect of the iodine. In 6 subjects with large multinodular goiters there was a marked rise in both T₃ and T₄) and reduction in the elevated basal TSH. Biochemical hyperthyroidism occurred in 3 of these subjects. The acute thyroid hormone response to iodized oil, whether inhibitory or stimulatory in a particular subject, depends both on goiter size and on the serum concentration of TSH. (J Clin Endocrinol Metah 42: 926, 1976)

Received August 7, 1975.

This article has been cited by other articles:

				P. E. Reith and D. K. Granner Iodine-Induced Thyrotoxicosis in a Woman With a Multinodular Goiter Taking Levothyroxine Arch Intern Med, February 1, 1985; 145(2): 355 - 356. [Abstract] [PDF]