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Journal of Clinical Endocrinology & Metabolism, Vol 42, 894-900, Copyright © 1976 by Endocrine Society

ARTICLES

Urine aldosterone radioimmunoassay: validation of a method without chromatography

RD Brown, A Swander and JK McKenzie

A simplified radioimmunoassay of urinary aldosterone is reported. Acid- hydrolyzed urine was extracted with dichloromethane and the extract assayed without further purification, Urinary aldosterone values in patients with Cushing's syndrome, low and normal-renin essential hypertension, congenital adrenal hyperplasia, and primary aldosteronism determined by this method agreed closely (r = 0.95, P less than 0.01) with values obtained using a standardized chromatographic method. This simplified assay represents a significant advance in out capabilitites for evaluating patients for abnormalities in aldosterone physiology.




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Copyright © 1976 by The Endocrine Society