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Urinary Excretion of Cyclic Adenosine 3',5'-Monophosphate in Children of Different Ages

Maryland Institute for Emergency Medicine, University of Maryland Hospital 22 S. Greene Street, Baltimore, Maryland 21201

Supported by National Institutes of Health Grant GM-15700.

The urinary excretion of cyclic AMP was investigated in 97 healthy children, 3 months to 16 years old. When the excretion was expressed as µmol/24 h an increase with age (r = 0.693, P < 0.001) and an increase with body weight (r = 0.700, P < 0.001) were found to be quite similar. In relation to surface area, the average excretion for children up to 9 years old was 4.45 ± 1.71 µmol/m² in contrast with 2.22 ± 0.66 µmol/m² in older children (P < 0.001). The decline appears to be associated with approaching puberty.

When cAMP excretion was related to urinary creatinine, an inverse correlation with age was found (r = –0.772, P < 0.001). In the youngest category, 3 months to 4 years old, the ratio was 9.26 ± 1.49 µmol/g creatinine vs 4.67 ± 1.05 µmol/g creatinine in the age group 12 to 16 years old (P < 0.001), which compares closely with the normal adult average of 4.34 ± 1.25 µmol/g creatinine found in our previous study. Throughout there was no evidence of sex differentiation.

Received May 30, 1975.

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