help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Journal of Clinical Endocrinology & Metabolism Vol. 42, No. 4 778-781
doi:10.1210/jcem-42-4-778
Copyright © 1976 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MCKENZIE, J. M.
Right arrow Articles by ZAKARIJA, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MCKENZIE, J. M.
Right arrow Articles by ZAKARIJA, M.

A Reconsideration of a Thyroid-Stimulating Immunoglobulin as the Cause of Hyperthyroidism in Graves' Disease

J. M. MCKENZIE and M. ZAKARIJA

McGill University Clinic, Royal Victoria Hospital Montreal, P.Q., Canada

This work was supported financially by grants from the US Public Health Service (AM04121) and the Medical Research Council of Canada (MT884 and MA5190) of which J. M. McKenzie is a Research Associate.

Several assays for thyroid-stimulating immunoglobulins in the blood in patients with Graves' disease have been described recently; depending upon the method, different names have been used and distinct entities thus implied. Using an increase in cyclic AMP in the human thyroid slice after 2 h of incubation as an index of thyroid stimulation, we identified thyroid-stimulating activity in all of an unselected series of sera from 11 patients with hyperthyroidism of Graves' disease, but long-acting thyroid stimulator, by mouse bioassay, in only three. The theory is proposed that the thyroid-stimulating immunoglobulin is probably present in all such patients; it may be seen as a polyclonal antibody to a single human antigen that has a variable cross-reaction with a corresponding thyroid antigen in the mouse and in other species.

Received July 24, 1975.




This article has been cited by other articles:


Home page
 Arch NeurolHome page
W. R. Kiessling
Thyroid Function in 44 Patients With Amyotrophic Lateral Sclerosis
Arch Neurol, April 1, 1982; 39(4): 241 - 242.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
B. A. Buckingham, G. Costin, T. F. Roe, J. J. Weitzman, and M. D. Kogut
Hyperthyroidism in Children: A Reevaluation of Treatment
Arch Pediatr Adolesc Med, February 1, 1981; 135(2): 112 - 117.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
M. ZAKARIJA, J. M. McKENZIE, and K. BANOVAC
Clinical Significance of Assay of Thyroid-Stimulating Antibody in Graves' Disease
Ann Intern Med, July 1, 1980; 93(1_Part_1): 28 - 32.
[Abstract] [PDF]

Home page
 JAMAHome page
M. V. Pilepich, I. Jackson, J. E. Munzenrider, and R. S. Brown
Graves' Disease Following Irradiation for Hodgkin's Disease
JAMA, September 22, 1978; 240(13): 1381 - 1382.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
J. BROWN, D. H. SOLOMON, G. N. BEALL, P. I. TERASAKI, I. J. CHOPRA, A. J. VAN HERLE, and S.-Y. WU
Autoimmune Thyroid Diseases--Graves' and Hashimoto's
Ann Intern Med, March 1, 1978; 88(3): 379 - 391.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1976 by The Endocrine Society