This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by KULIN, H. E. Articles by SANTNER, S. J. Search for Related Content PubMed PubMed Citation Articles by KULIN, H. E. Articles by SANTNER, S. J.

Circadian Rhythms in Gonadotropin Excretion in Prepubertal and Pubertal Children

Division of Endocrinology, Department of Pediatrics, the Milton S. Hershey Medical Center of Pennsylvania State University Hershey, Penna. 17033

A preliminary report of this work was presented at the Sixth Brook Lodge Conference, Regulatory Mechanisms of Male Reproductive Physiology, Kalamazoo, Michigan, October, 1975.

Timed urinary collections were obtained during sleep and waking hours from 27 prepubertal children ranging in age from 2–12 years and from 13 subjects in various stages of puberty, 12–18 years old. The urine samples were extracted with acetone and introduced into FSH and LH radioimmunoassays. Results of the study indicate a significant nocturnal augmentation of LH secretion in pubertal subjects, confirming existing reports using blood sampling techniques. Increased LH and FSH excretion during sleep was also found in prepubertal children.

Received September 11, 1975.

This article has been cited by other articles:

				C. D. Foradori, L. R. Hinds, W. H. Hanneman, M. E. Legare, C. M. Clay, and R. J. Handa Atrazine Inhibits Pulsatile Luteinizing Hormone Release Without Altering Pituitary Sensitivity to a Gonadotropin-Releasing Hormone Receptor Agonist in Female Wistar Rats Biol Reprod, July 1, 2009; 81(1): 40 - 45. [Abstract] [Full Text] [PDF]

				G.B. Kletter, V. Padmanabhan, I.Z. Beitins, J.C. Marshall, R.P. Kelch, and C.M. Foster Acute Effects of Estradiol Infusion and Naloxone on Luteinizing Hormone Secretion in Pubertal Boys J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4010 - 4014. [Abstract] [Full Text] [PDF]

				P. C. Sizonenko Endocrinology in Preadolescents and Adolescents: I. Hormonal Changes During Normal Puberty Arch Pediatr Adolesc Med, July 1, 1978; 132(7): 704 - 712. [Abstract] [PDF]