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Journal of Clinical Endocrinology & Metabolism, Vol 42, 770-773, Copyright © 1976 by Endocrine Society

ARTICLES

Circadian rhythms in gonadotropin excretion in prepubertal and pubertal children

HE Kulin, RG Moore Jr and SJ Santner

Timed urinary collections were obtained during sleep and waking hours from 27 prepubertal children ranging in age from 2-12 years and from 13 subjects in various stages of puberty, 12-18 years old. The urine samples were extracted with acetone and introduced into FSH and LH radioimmunoassays. Results of the study indicate a significant nocturnal augmentation of LH secretion in pubertal subjects, confirming existing reports using blood sampling techniques. Increased LH and FSH excretion during sleep was also found in prepubertal children.


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