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,
GEORGE KIMMERLING
,
PHYLLIS CRAPO and
GERALD M. REAVEN
Department of Medicine, Stanford University School of Medicine and Veterans Administration Hospital Palo Alto, California
Reprints: Gerald M. Reaven, M.D., Veterans Administration Hospital, 3801 Miranda Ave., Palo Alto, Calif. 94304.
We have studied the effects of moderate dietary fat restriction on plasma triglyceride, cholesterol, glucose, and insulin response in 27 subjects. Compared with a control diet (45% fat, 40% carbohydrate [CHO], 15% protein) the low fat (higher CHO) diet (30% fat, 55% CHO, 15% protein) produced a 41% increase in fasting triglyceride level (155 ± 17 to 219 ± 23 mg%) with no change in fasting plasma cholesterol level. Furthermore, this increase in triglyceride levels; induced by the higher CHO content of the low fat diet, was seen in 26 out of 27 subjects. Postprandial triglyceride, glucose, and insulin levels were also higher on the low fat (higher CHO) diet. Since hypertriglyceridemia is a significant risk factor for the development of coronary heart disease, and since our data indicate that the moderate increase in dietary CHO associated with a low fat diet will elevate plasma triglyceride levels, we believe that more caution is necessary before recommending the wide-spread use of low fat diets for heart disease prevention.
Supported in part by NHLI NIH Grant no. HL08506, GCRC Grant no. FR70, and by the Veterans Administration.
* Dr. Ginsberg was a Resident Clinical Associate, MRIS #3412, Veterans Administration. Present address: Naval Regional Medical Center, San Diego, California.
Dr. Olefsky is a Clinical Investigator, MRIS #6488, Veterans Administration.
Dr. Kimmerling was a Resident Clinical Associate, MRIS #4932, Veterans Administration.
Dr. Reaven is a Medical Investigator, MRIS #7363, Veterans Administration.
Received August 11, 1975.
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