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Demonstration of Antibodies to Testicular Basement Membrane by Immunofluorescence in a Patient with Multiple Primary Endocrine Deficiencies

The Departments of Medicine, Pathology and Surgery, Veterans Administration Hospital Northport, New York 11768
Departments of Medicine, Pathology and Surgery, State University of New York Stony Brook, New York 11790

Circulating antibodies directed against testicular basement membrane and germinal cells are demonstrated in a patient with multiple primary endocrine gland deficiencies involving the thyroid, adrenals, testes, and pernicious anemia. Testicular biopsy revealed focal destruction of seminiferous tubules and interstitial fibrosis. The tubular basement membranes showed sharply positive immunofluorescence when stained with the patient's FITC conjugated gamma globulins.

Received July 22, 1975.