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Journal of Clinical Endocrinology & Metabolism, Vol 42, 88-90, Copyright © 1976 by Endocrine Society

ARTICLES

The effect of ACTH administration on serum estrogens, LH, and FSH in the aged

T Murakami, T Yamaji and N Ohsawa

The effect of administration of long acting ACTH on serum levels of estrogens, LH and FSH was studied in aged subjects. Nine women and 5 men between 66 and 90 years of age were examined. One milligram of long- acting synthetic ACTH was given in every 12 h for 2 days. Significant increases in serum estrone and estradiol levels were induced in parallel with serum cortisol at 24 hours and no further change was observed at 48 hours. The estrone/estradiol ratio increased from a control value of 3.0 to 4.0 at 24 hours and to 4.7 at 48 hours (P less than 0.02) compared to control values.




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Copyright © 1976 by The Endocrine Society