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Journal of Clinical Endocrinology & Metabolism, Vol 42, 177-180, Copyright © 1976 by Endocrine Society

ARTICLES

Catechol estrogen formation by the human fetal brain and pituitary

J Fishman, F Naftolin, IJ Davies, KJ Ryan and Z Petro

Homogenates of central neuroendocrine tissues from 2 male and 1 female midtrimester fetuses were incubated with (23H) estradiol-17beta. Metabolism at the C-2 position was monitored by measuring the tritium incorporated into water in the incubate. Liberation of tritium from the substrate by hypothalamus, limbic tissues, parietal cortex and pituitary occurred to the extent of 5.1-12.7%, 1.6-8.5%, 4.7-10.8%, and 0.9-4.1% of starting radioactivity, respectively. The nature of the product was confirmed by the isolation of 14C labelled 2-hydroxyestrone derivative from separate incubations with 14C-estrone as the substrate. With or without correction for weight of tissue incubated, catechol estrogen formation under these conditions occurs at levels similar to those seen in rat brain homogenates except that in contrast to the rat, the human cortex is also highly active.


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J Fishman and D Tulchinsky
Suppression of prolactin secretion in normal young women by 2-hydroxyestrone
Science, October 3, 1980; 210(4465): 73 - 74.
[Abstract] [PDF]


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