Journal of Clinical Endocrinology & Metabolism, Vol 41, 989-991, Copyright © 1975 by Endocrine Society

ARTICLES

Influence of body weight on estradiol metabolism in young women

J Fishman, RM Boyar and L Hellman

The metabolism of estradiol in girls with anorexia nervosa was compared with obese subjects and normal weight, age and sex matched controls. Increasing body weight was accompanied by a sharp decrease in 2- hydroxylation of estradiol and an increase in 16alpha-hydroxylation. These metabolic changes are discussed in terms of the biological activity of 2-hydroxyestrone and estriol.

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