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Journal of Clinical Endocrinology & Metabolism, Vol 41, 974-976, Copyright © 1975 by Endocrine Society

ARTICLES

The effect of short-term triiodothyronine administration on thyroxine response to exogenous TSH in man

R Vigneri, S Squatrito, V Pezzino, S Filetti and P Polosa

In order to examine whether thyroid hormone concentration interfere with the thyroid gland responsivity to TSH, paired studies on the effect of short-term T3 treatment on T4 response to exogenous TSH ( 5 I.U. i.m.) were carried out in 10 euthyroid volunteers. During T3 administration ( 120 mcg/day for 4 days starting 48 hr before TSH injection) a significant decrease in T4 concentrations was observed both prior to and after TSH, with an inhibition of the T4 response ranging from 36-77% as calculated from the area under the response curve. The present data are in agreement with the existence of a "short- loop" thyroid-thyroid regulatory mechanism in man. In fact, the decreased percent rise of T4 after TSH suggests an inhibitory effect of T4 release following TSH, even though a modification of T4 kinetic parameters during T3 administration may account for a portion of the lowering of T4 blood concentrations.




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Copyright © 1975 by The Endocrine Society