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Journal of Clinical Endocrinology & Metabolism, Vol 41, 791-792, Copyright © 1975 by Endocrine Society

ARTICLES

Interference of spironolactone in 11-doexycorticosterone radioassays

SY Tan and PJ Mulrow

Uniformly elevated plasma 11-deoxycorticosterone (DOC) values are obtained in patients receiving spironolactone. This elevation is shown to be spurious, and is a result of cross-interference of spironolactine and its metabolite, canrenone, in both the DOC radioimmunoassay and competitive protein-binding radioassay.




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Copyright © 1975 by The Endocrine Society