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Journal of Clinical Endocrinology & Metabolism, Vol 41, 656-659, Copyright © 1975 by Endocrine Society

ARTICLES

Recovery from paradoxical growth hormone responses in acromegaly after transphenoidal selective adenomectomy

KM Hoyte and JB Martin

A patient with acromegaly was studied before and after treatment by transphenoidal removal of a pituitary adenoma. "Paradoxical" GH responses to the dopamine agonists L-DOPA and ampomorphine disappeared after surgery, with reversion of GH responsiveness to normal. TSH- releasing hormone (TRH)-induced GH release observed pre-operatively did not occur after surgery. The findings suggest that in certain cases, acromegaly is due to pituitary dysfunction alone.




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Copyright © 1975 by The Endocrine Society