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Journal of Clinical Endocrinology & Metabolism, Vol 41, 640-643, Copyright © 1975 by Endocrine Society

ARTICLES

Secondary drug failure occurring during chronic treatment with LHRH: appearance of an antibody

GR Van Loon and GM Brown

Secondary drug failure with regard to subjective and hormonal responses occurred in a patient treated chronically with LHRH. This failure of response to hormone therapy was correlated with increased binding of 125I-LHRH by the patient's sera. Also, competitive displacement of 125I- LHRH by unlabelled LHRH was demonstrated. Affinity constants and titers of order appropriate for antibody were obtained. These data support strongly a report of antibody formation to exogenous LHRH in man.


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[Abstract] [Full Text] [PDF]


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