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Journal of Clinical Endocrinology & Metabolism, Vol 41, 422-425, Copyright © 1975 by Endocrine Society

ARTICLES

Big growth hormone (GH): conversion to small GH without peptide bond cleavage

R Benveniste, ME Stachura, M Szabo and LA Frohman

Mercaptoethanol treatment of big growth hormone (GH) obtained from human pituitary resulted in a 60% conversion to small GH. Further dissociation was obtained by combined treatment with the reducing agent plus urea. The results indicate that the existence of big GH is dependent upon the formation of inter-polypeptide chain disulfide bonds.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1975 by The Endocrine Society