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Journal of Clinical Endocrinology & Metabolism, Vol 41, 408-411, Copyright © 1975 by Endocrine Society

ARTICLES

Suppression by thyrotropin-releasing hormone (TRH) of human growth hormone release induced by L-dopa

K Maeda, Y Kato, K Chihara, S Ogo and Y Iwasaki

Oral administration of L-dopa (600 mg) significantly raised plasma human growth hormone (hGH) in 6 of 7 normal subjects examined. This L- dopa induced hGH release was significantly suppressed by the intravenous infusion of 1 mg of thyrotropin-releasing hormone (TRH). TRH administration alone had no significant effect on plasma hGH. In contrast, plasma human prolactin (hPRL) consistently increased following TRH infusion. L-dopa significantly lowered basal plasma hPRL levels and also significantly blunted TRH-induced hPRL release. These results suggest that TRH plays an inhibitory role in the regulation of hGH secretion in normal subjects, whereas it stimulates hPRL release.




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Copyright © 1975 by The Endocrine Society