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Journal of Clinical Endocrinology & Metabolism, Vol 41, 380-382, Copyright © 1975 by Endocrine Society

ARTICLES

The effect of chlorpromazine on the secretion of immunoreactive beta- MSH and prolactin in man

NA Plummer, AJ Thody, JL Burton, SK Goolamali, S Shuster, EN Cole and AR Boyns

The effect of chlorpromazine (50 mg. im) on the plasma concentration of immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) and prolactin was studied in 8 hospitalized subjects with non-endocrine skin disorders. Plasma beta-MSH concentrations remained unchanged over a period of 7 h in 6 subjects. In the remaining 2 subjects there was a slight increase. Plasma prolactin concentrations were greatly increased in all subjects 1 1/2-3 h after the injection and had almost returned to pre-injection levels by 7 h. This suggests that the control of beta- MSH secretion in man, unlike that of prolactin in man and MSH peptides in other mammals, is not predominantly inhibitory. The reason for this discrepancy may be that beta-MSH is not a natural MSH in man and occurs as part of the lipotropic hormone (LPH) or as a breakdown product.




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Copyright © 1975 by The Endocrine Society