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Variations of Neurohypophysial Function in Normally Cycling Women

^* Department of Internal Medicine of Hopital de Baviere University of Liege Belgium
Medical Research Centre, Prince Henry's Hospital Melbourne, Australia

Using a neurophysin radioimmunoassay, we have studied basal neurohypophysial function in seven normal women. An increase in neurophysin blood levels has been demonstrated during the ovulatory and/or luteal phase as compared to the follicular phase; these variations are related to the changes in the circulating levels of 17β-estradiol.

The data provide additional evidence for a relationship between estrogens and neurohypophysial function, as previously shown following exogenous administration of estriol and ethinyl estradiol in man.

Received October 8, 1973.