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The Role of Estrogen in the Modulation of Pituitary Sensitivity to LRF (Luteinizing Hormone-Releasing Factor) in Men¹

Department of Reproductive Medicine, School of Medicine, University of California, San Diego La Jolla, California 92037

The role of estradiol in modulating pituitary gonadotropin release in the human male was studied by evaluating the effects of clomiphene on the pituitary gonadotropin response to synthetic LRF (150 µg) in 6 eugonadal men. Administration of clomiphene (100 mg single daily dose x 5 days) induced a significant elevation of the basal levels of LH, FSH, estradiol and testosterone. However, the pituitary release of LH and FSH in response to LRF was markedly diminished by the clomiphene treatment. This finding suggests that in men, as in women, endogenous estradiol provides feedback regulation of gonadotropin output by the pituitary.

¹ This work was supported by Rockefeller Founda-tion Grant RF 70029 and AID/csd/2785.

² Research Fellow in Reproductive Endocrinology,supported by Rockefeller Foundation Grant RF70029.

³ Research Fellow in Reproductive Endocrinology,supported by Rockefeller Foundation Fellowship.

Received November 7, 1974.