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Glucagon Stimulation of Plasma Renin Activity in Humans

The Department of Medicine, Yale University School of Medicine New Haven Connecticut 06510

Please address reprint requests to Robert H. Noth, M.D., Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.

Administration of 0.2 mg of glucagon by intravenous bolus resulted in an increase in plasma renin activity (PRA) in 2 of 5 normal volunteers on their usual diet. Two of the nonresponders subsequently showed a PRA response to glucagon after sodium depletion. A lower dose of glucagon (0.01 mg) had no effect on PRA despite a 31 mg/100 ml rise in blood glucose and a peak plasma glucagon of over 2000 pg/ml. In conclusion, glucagon can stimulate PRA but it is not a potent stimulator; its effect may be potentiated by sodium depletion.

^* Present address: Department of Internal Medicine, Hospital Clinico de San Carlos, Madrid 3, Spain,

This work was supported by Public Health Service Grant HL 12758.

Received January 20, 1975.