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Effect of Calcitonin on Serum Gastrin Concentration and Component Pattern in Man

Departments of Medicine (T) and Clinical Chemistry, Bispebjerg Hospital Copenhagen, Denmark

Synthetic salmon calcitonin (_sCT, doses of 0.7 Medical Research Council U per kg) was injected into nine normal subjects and three patients with hypergastrinemia (pernicious anemia). _sCT depressed basal as well as food-stimulated serum gastrin concentrations without concomitant changes in total and ultrafiltrable concentrations of calcium in serum. Gel filtration of sera revealed that _sCT reduced mainly the small components, III (gastrin-17 or "little" gastrin) and IV (gastrin-13 or "mini"-gastrin).

Received February 7, 1975.

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