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Journal of Clinical Endocrinology & Metabolism, Vol 41, 149-152, Copyright © 1975 by Endocrine Society

ARTICLES

Effect of calcitonin on serum gastrin concentration and component pattern in man

J Fahrenkrug, I Hornum and JF Rehfeld

Synthetic salmon calcitonin (sCT, doses of 0.7 Medical Research Council U per kg) was injected into nine normal subjects and three patients with hypergastrinemia (pemicious anemia). sCT depressed basal as well as food-stimulated serum gastrin concentrations without concomitant changes in total and ultrafiltrable concentrations of calcium in serum. Gel filtration of sera revealed that sCT reduced mainly the small components, III (gastrin-17 or "little" gastrin) and IV (gastrin-13 or "mini"-gastrin).


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