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Journal of Clinical Endocrinology & Metabolism, Vol 40, 1125-1127, Copyright © 1975 by Endocrine Society

ARTICLES

Inhibition by somatostatin of ACTH secretion in Nelson's syndrome

JB Tyrrell, M Lorenzi, JE Gerich and PH Forsham

Somatostatin (GHIF), when administered as a 1-hr infusion (500 mug/hr) to 5 patients with Nelson's Syndrome;resulted in a sustained, progressive fall in plasma ACTH in each patient to 40% to 71% of basal values with a return toward initail levels after cessation of the infusion. The meanreduction in plasma ADTH was 48% (p less than 0.005). These finding suggest that GHIF receptors not fuctional or present in normal pituitary tissue are present in ACTH-producing pituitary tumors.


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